Inhoudsopgave:
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\u003cp\u003e\u003ci\u003eValidamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity\u003c/i\u003e presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.\u003c/p\u003e \u003cp\u003eBeginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. \u003c/p\u003e \u003cp\u003eBiological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. \u003c/p\u003e \u003cp\u003eFinally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.\u003c/p\u003e\u003cul\u003e \u003cli\u003eOffers complete coverage of validamycin chemistry from a highly experienced team of authors \u003c/li\u003e \u003cli\u003eEncourages the discovery of further novel drugs based on validamycin derivatives\u003c/li\u003e \u003cli\u003ePresents an interesting model for establishing new pharmaceutical leads from agricultural sources\u003c/li\u003e \u003cli\u003eIncludes coverage of the total chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine and validoxylamines\u003c/li\u003e\u003c/ul\u003e |
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