In this issue of \u003ci\u003eOrthopedic Clinics\u003c/i\u003e, guest editors from the esteemed Campbell Clinic bring their considerable expertise to the topic of \u003cb\u003eIntraoperative Challenges\u003c/b\u003e. Eleven top experts discuss a wide variety of potential surgical challenges that require the surgeon to make important judgment calls and decide the proper course of action. Areas covered include knee and hip reconstruction, hand and wrist, foot and ankle, shoulder and elbow, spine, trauma, and pediatrics.\u003cul\u003e\u003cli\u003eContains \u003cb\u003e14 relevant, practice-oriented topics\u003c/b\u003e including challenges with intraoperative imaging for pelvic and acetabular surgery; neuromonitoring changes in spinal deformity surgery; intraoperative challenges in hand surgery; managing intraoperative fractures during total ankle replacement; intraoperative vertebral artery injury: evaluation, management and prevention; and more.\u003c/li\u003e\u003cli\u003eProvides in-depth \u003cb\u003eclinical reviews on intraoperative challenges\u003c/b\u003e, offering actionable insights for clinical practice.\u003c/li\u003e\u003cli\u003ePresents the \u003cb\u003elatest information on this timely, focused topic\u003c/b\u003e under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.\u003c/li\u003e\u003c/ul\u003e